Erythema gyratum repens egr, first described by gammel,1 in 1952, is a rare paraneoplastic syndrome typically associated with an underlying malignancy. Erythema gyratum perstans information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. A metastatic, undifferentiated adenocarcinoma was removed following a. Erythema gyratum repens eruption has been noted after surgery, chemotherapy, or radiotherapy. In about of cases the disease is not tumorassociated. Erythema gyratum repens induced by pegylated interferon.
This case report details the appearance, epidemiology, diagnosis, and treatment of egr. In addition, there is some types of gyrate erythema could be misdiagnosed as egr such as. Thank you for helping build the largest language community on the internet. Erythema nodosum en, is an inflammatory condition characterized by inflammation of the fat cells under the skin, resulting in tender red nodules or lumps that are usually seen on both shins. Cold urticaria familial primary cold contact urticaria secondary cold contact urticaria reflex cold urticaria. Erythema gyratum repens is a figurate erythema that is rapidly moving and usually a marker of underlying cancer, 1 2 3. Erythema gyratum repens is a rare facultative cutaneous paraneoplasia. A cavitating mass at the right lung apex was resected and proved to be tuberculous. Annular erythema is not a diagnostic term but rather a description of a spreading erythematous eruption with an annular ringshaped appearance. In this case report, we describe the condition of a 61yearold woman who presented with a generalized pruritic eruption that was shown to be egr. Erythema nodosum is often associated with systemic diseases such as tuberculosis and rheumatic fever. Erythema gyratum repens egr is a rare, and characteristic, rash strongly associated with malignancy. In common with all previous reports, both were found to have a hitherto unsuspected underlying neoplasm, one having an adenocarcinoma of the bladder and the other a prostatic carcinoma. Erythema gyratum repens is a rare paraneoplastic type of annular erythema with a distinctive figurate woodgrain appearance.
How and why the condition occurs is unknown, although it is thought it. Erythema gyratum repens wikimili, the free encyclopedia. Erythema anulare centrifugum eac, is a descriptive term for a class of skin lesion presenting redness in a ring form anulare that spreads from a center centrifugum. Erythema gyratum repens egr is a rare and characteristic, paraneoplastic rash associated with a variety of malignancies, most notably lung, esophageal, and breast cancers. Volume 47, issue 5, supplement, november 2002, pages s254s256. Erythema gyratum repens egr is a figurate erythema that is believed to be a paraneoplastic process. Transformation from pityriasis rubra pilaris to erythema. Paraneoplastic bullous pemphigoid resembling erythema gyratum repens. If the expansion of the rash is not uniform it may become arciform arclike or polycyclic two or more connected rings. An erythema gyratum repens variant of bullous lupus. Most of the body is covered in numerous serpiginous bands arranged in.
Erythema gyratum repens like eruption erythema gyratum repens like appearance in pemphigus foliaceus. Many different terms have been used to classify these types of lesions and it is still controversial on what exactly defines eac. Egr is associated with malignancy, most commonly bronchial, esophageal, and breast, in more than 80% of cases. Erythema gyratum repens is a figurate erythema that is rapidly moving and usually a marker of underlying cancer. Annular erythema primary care dermatology society uk. Nevertheless, a diagnosis of erythema gyratum repens warrants an in depth search for possible underlying malignancies. Erythema gyratum repens is not an obligate paraneoplastic disease. Erythema gyratum repens wikipedia republished wiki 2. While there are many dermatoses that have an annular appearance, the term annular erythema is sometimes reserved for a group of. Erythema gyratum repens associated with anal cancer list of authors.
Erythema gyratum repens egr is rare, and the primary lesion is a serpiginous macular, occasionally popular, erythema 210. Bullous lupus erythematosus is an autoantibodymediated subepidermal blistering disease that occurs in patients with systemic lupus erythematosus sle. Cd4cd8 doublenegative mycosis fungoides mimicking erythema gyratum repens in a patient with underlying lung cancer. Erythema gyratum repens is rare and is the most distinctive of the gyrate erythemas. Erythema gyratum repens like appearance in pemphigus foliaceus. Erythema gyratum repens has not previously been described in association with non. Prompt identification of egr is essential, as the rash often precedes the diagnosis of malignancy by several months. Erythema gyratum repens as a manifestation of drug. Erythema gyratum repens also known as gammels disease is a figurate erythema that is rapidly moving and usually a marker of underlying cancer. Erythema gyratum repens egr is an uncommon condition defining a type of skin lesion pattern, in which red skin rashes composed of concentric rings annular erythema moves. Serrao v, martins a, ponte p, baptista j, apetato m, feio ab. Erythema gyratum repens an overview sciencedirect topics. Erythema gyratum repens egr is a rare disease characterized by the cutaneous eruption of migratory concentric erythematous bands. Erythema gyratum repens with metastatic adenocarcinoma.
Erythema gyratum repens as a manifestation of drug reaction with eosinophilia and systemic symptoms. Sarita sasidharanpillai 1, saleem rahima 1, manikoth payyanadan binitha 1, ettapurath n abdul latheef 1, aparna govindan 2, dhanya prashant 3, rajwa rahman 1. Erythema gyratum repens is a clinically distinctive figurate or annular erythema that is usually associated with underlying malignancy. Erythema gyratum repens is associated with malignancy in as many as 80% of patients. Erythema gyratum repens appears as concentric, scaly bands of erythema in a gyrate pattern, forming a wood grain appearance. Erythema gyratum article about erythema gyratum by the. Most patients with erythema gyratum repens develop the eruption. Following the resection, the skin lesions cleared within a few days. According to medscape, fewer than 100 cases are found in medical literature. Erythema gyratum repens with pulmonary tuberculosis. Neutrophilic dermatosis, bullous dermatoses, and systemic lupus erythematous gyratum repens 3. It is common in young people between 1220 years of age. Erythema gyratum repens associated with anal cancer nejm.
Tender, bright red, slightly elevated nodules develop along the shins. Erythema gyratum repens egr, considered one of the most specific cutaneous paraneoplastic phenomena, is characterized by a serpiginous morphology and a migrating scaly border. A patient with erythema gyratum repens egr had a marked increase of his eruption, with uncontrollable pruritus that was unresponsive to steroid therapy. Summary the case histories of 2 patients with erythema gyratum repens e.
It occurs with any skin injury, infection, or inflammation. In addition to other features, characteristic concentric erythematous bands forming a woodgrain appearance help distinguish erythema gyratum repens from other figurate erythemas, such as erythema annulare centrifugum, erythema migrans, and e. Leukocytoclastic vasculitis presenting as an erythema gyratum repens like eruption on a patient with systemic lupus erythematosus. Pdf erythema gyratum repenslike eruption occuring in. A 73yearold woman presented with an evolving pruritic, erythematous rash and was. The eruption is rapidly migrating and composed of concentric rings forming a woodgrain pattern histology of erythema gyratum repens. It can be caused by a variety of conditions, and typically resolves spontaneously within 30 days. The condition, first described by gammel in 1952, is also referred to as gammels disease. There are many types of erythema, or conditions causing rash and reddening of the skin, but erythema gyratum repens typically appears because of an underlying condition. Listen to the audio pronunciation of erythema gyratum repens on pronouncekiwi.
Repens repercolation repercussion repercussive repetabs repetat. Leukocytoclastic vasculitis presenting as an erythema. Erythema gyratum repens like eruption occuring in resolving psoriasis during methotrexate therapy. Initial symptoms can be uncharacteristic, wood grain pattern lesions develop only in mature stages. Erythema gyratum repens like eruptions with large cell transformation in a patient with mycosis fungoides. Erythema gyratum repens is a rare figurate condition that has been reported to be related to an underlying tumor in 82% of cases. Erythema gyratum definition of erythema gyratum by. The most common include lung carcinoma, oesophageal carcinoma and breast carcinoma.
Eritrodermia exfoliativa pdf english translation, synonyms, definitions and usage examples of spanish word eritrodermia exfoliativa. Erythema gyratum repens with associated squamous cell carcinoma of the lung. Erythema gyratum repens has also been noted in association with several nonmalignant conditions such as tuberculosis, linear iga dermatosis, psoriasis, pityriasis rubra pilaris, pemphigus vulgaris, bullous pemphigoid, ichthyosis, and hypereosinophilic syndrome. A computed tomographic scan revealed a pulmonary mass measuring 59 by 43 mm panel b. Erythema gyratum repens as the initial manifestation of lung cancer. Erythema annulare centrifugum erythema marginatum erythema migrans erythema gyratum repens. A clinical diagnosis of erythema gyratum repens was made. Erythema gyratum repens has also been associated with anal cancer. A case studied with immunofluorescence, immunoelectronmicroscopy and immunohistochemistry. Histological features of erythema gyratum repens are not diagnostic and include hyperkeratosis, parakeratosis, acanthosis and. In the majority of instances cancer is the culprit, however, certain autoimmune diseases or infections may give rise. Among visceral malignancies, the lung is the most common site, 7, 8, 9 followed by the breast, urinary bladder, uterus andor cervix, gi tract stomach, and prostate. Request pdf erythema gyratum repens is not an obligate paraneoplastic disease.
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